Not really the way it works.
Reduced accuracy still means reduced accuracy for Hyperion guns too, it just reverses WHEN you feel the effect.
The reason this still works great is that those COMs like the Renegade and Cat don’t actually reduce accuracy by much and the difference is barely noticeable. Also, Hyperion pistols are so accurate to begin with that a small penalty like that will have no measurable impact in play.
I love the Legendary Cat + Bitch combo on Maya. You don’t really feel that accuracy penalty at all and the COM’s damage boost plus the Bitch’s crit boost really make popping sustained critical hits fun.